[ASC-list] Seminar Targeted Nanosponges as Superior Delivery Systems: Practical Synthesis and Efficacy Testing

Jayne Keane jayne.keane at qm.qld.gov.au
Thu Jun 21 00:25:55 UTC 2012

Presenter: Professor Eva Harth, Department of Chemistry, Vanderbilt University

Title: Targeted Nanosponges as Superior Delivery Systems: Practical Synthesis and Efficacy Testing

Date: Friday 29 June 2012

Time: 10:00am

Venue: AIBN Level 1 Seminar Room


Abstract:  Nanoscopic delivery devices have been recently received considerable attention due to the ability to combine features that are difficult to achieve with a drug alone. The presented delivery system, features a 3‐D nanoscopic degradable organic network, that similar to sponges can entrap the drug molecule in the interior. Furthermore, the globular nano‐network can be functionalized with targeting units to guide the delivery system to the tumor cell and vasculature. The developed Click‐chemistries allow for an easy attachment and do not compromise the nanoparticle backbone or the peptide targeting units. We have investigated three different targeting units that are able to deliver the device to a variety of cancer types. Tailored linear release kinetics have been developed that release the drug in a constant rate that can be tuned to a fast, medium and slow release. These drug release profiles governed by the versatility in the nanosponge design are suited to personalize clinical protocols and prevent over or under‐dosing of the therapeutic. We have observed in three tumor models an up to five fold higher efficacy of drug molecules as the result of a combination of drug solubility, release and targeting.


Bio:  Eva Harth was born in Cologne, Germany and studied chemistry at the University of Bonn and the University of Zurich, Switzerland. She obtained her PhD in 1998 for work in the area of fullerene adducts and polymers from the MPI for Polymer Research in Mainz. A postdoctoral fellowship with CPIMA (NSF‐Center for Polymer Interfaces and Macromolecular Assemblies) brought her to the IBM Almaden Research Center, California USA, to work under the direction of Prof. Craig J. Hawker, focusing on the development of new living free polymerization techniques and approaches to nanoscopic materials. In 2001, she joined XenoPort, Inc. as a Staff Scientist investigating enabling technologies for the increased bioavailability of macromolecular therapeutics. After the extensive industrial experience, she started at Vanderbilt University as Assistant Professor in the Department of Chemistry in 2004 with a secondary appointment in the Department of Pharmacology, Vanderbilt Medical School and was promoted to Associate Professor in 2011. In 2007, she was awarded with the NSF CAREER Award for young faculty and her research advances delivery technologies across challenging biological barriers and towards highly vascular tumors.


Please contact Prof. Michael Monteiro (m.monteiro at uq.edu.au) for more information.



******************* Disclaimer *******************
The contents of this electronic message and any attachments are intended only for the addressee and may contain privileged or confidential information. 
They may only be used for the purposes for which they were supplied.
If you are not the addressee, you are notified that any transmission, distribution, downloading, printing or photocopying of the contents of this message 
or attachments is strictly prohibited. 
The privilege of confidentiality attached to this message and attachments is not waived, lost or destroyed by reason of mistaken delivery to you. 
If you receive this message in error please notify the sender by return e-mail or telephone. 
Please note: the Queensland Museum carries out automatic software scanning, filtering and blocking of E-mails and
attachments (including emails of a personal nature) for detection of viruses, malicious code, SPAM, executable programs or content it deems unacceptable. 
All reasonable precautions will be taken to respect the privacy of individuals as outlined in the QM Privacy Plan. 
Personal information will only be used for official purposes, e.g. monitoring Departmental Personnel's compliance with Museum Policies. 
Personal information will not be divulged or disclosed to others, unless as required by Museum Policy and/or State or Commonwealth Law.
******************** Disclaimer *******************

-------------- next part --------------
An HTML attachment was scrubbed...
URL: <https://www.lists.sublimeip.com/pipermail/asc-list/attachments/20120621/91b318ce/attachment.htm>

More information about the ASC-list mailing list