[ASC-list] Seminar Targeted Nanosponges as Superior Delivery Systems: Practical Synthesis and Efficacy Testing
jayne.keane at qm.qld.gov.au
Thu Jun 21 00:25:55 UTC 2012
Presenter: Professor Eva Harth, Department of Chemistry, Vanderbilt University
Title: Targeted Nanosponges as Superior Delivery Systems: Practical Synthesis and Efficacy Testing
Date: Friday 29 June 2012
Venue: AIBN Level 1 Seminar Room
Abstract: Nanoscopic delivery devices have been recently received considerable attention due to the ability to combine features that are difficult to achieve with a drug alone. The presented delivery system, features a 3‐D nanoscopic degradable organic network, that similar to sponges can entrap the drug molecule in the interior. Furthermore, the globular nano‐network can be functionalized with targeting units to guide the delivery system to the tumor cell and vasculature. The developed Click‐chemistries allow for an easy attachment and do not compromise the nanoparticle backbone or the peptide targeting units. We have investigated three different targeting units that are able to deliver the device to a variety of cancer types. Tailored linear release kinetics have been developed that release the drug in a constant rate that can be tuned to a fast, medium and slow release. These drug release profiles governed by the versatility in the nanosponge design are suited to personalize clinical protocols and prevent over or under‐dosing of the therapeutic. We have observed in three tumor models an up to five fold higher efficacy of drug molecules as the result of a combination of drug solubility, release and targeting.
Bio: Eva Harth was born in Cologne, Germany and studied chemistry at the University of Bonn and the University of Zurich, Switzerland. She obtained her PhD in 1998 for work in the area of fullerene adducts and polymers from the MPI for Polymer Research in Mainz. A postdoctoral fellowship with CPIMA (NSF‐Center for Polymer Interfaces and Macromolecular Assemblies) brought her to the IBM Almaden Research Center, California USA, to work under the direction of Prof. Craig J. Hawker, focusing on the development of new living free polymerization techniques and approaches to nanoscopic materials. In 2001, she joined XenoPort, Inc. as a Staff Scientist investigating enabling technologies for the increased bioavailability of macromolecular therapeutics. After the extensive industrial experience, she started at Vanderbilt University as Assistant Professor in the Department of Chemistry in 2004 with a secondary appointment in the Department of Pharmacology, Vanderbilt Medical School and was promoted to Associate Professor in 2011. In 2007, she was awarded with the NSF CAREER Award for young faculty and her research advances delivery technologies across challenging biological barriers and towards highly vascular tumors.
Please contact Prof. Michael Monteiro (m.monteiro at uq.edu.au) for more information.
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